Multidrug-resistant tuberculosis treatment with linezolid-containing regimen
نویسندگان
چکیده
منابع مشابه
Linezolid for the treatment of multidrug-resistant tuberculosis.
OBJECTIVES In vitro studies have shown good activity of linezolid against Mycobacterium tuberculosis, including multidrug-resistant strains. However, clinical experience with linezolid in tuberculosis is scarce. METHODS We report our clinical experience with five consecutive patients with multidrug-resistant tuberculosis infection treated with combination regimens that included linezolid. R...
متن کاملLinezolid for multidrug-resistant tuberculosis - authors' reply.
In their Comment in The Lancet Infectious Diseases, Kwok-Chiu Chang and colleagues concluded that expansion of access to linezolid for complicated cases of drug-resistant tuberculosis risks the loss of a potentially useful drug and could promote the emergence and spread of drug-resistant tuberculosis in the community. The rationale behind this idea seems to be the scarcity of controlled clinica...
متن کاملClarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients.
The use of linezolid for the treatment of multidrug-resistant tuberculosis is limited by dose- and time-dependent toxicity. Recently, we reported a case of pharmacokinetic drug-drug interaction between linezolid and clarithromycin that resulted in increased linezolid exposure. The aim of this prospective pharmacokinetic study is to quantify the effect of clarithromycin on the exposure of linezo...
متن کاملLinezolid tolerability in multidrug-resistant tuberculosis: a retrospective study.
Linezolid is used off-label to treat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) [1, 2]. Recently, two systematic reviews and meta-analyses pointed out its promising efficacy [3, 4]. However, linezolid toxicity may outweigh its potential benefits. Indeed, adverse events were notified in almost 60% of the treated cases, with a high incidence of severe events ...
متن کاملLinezolid for multidrug-resistant tuberculosis: How should we approach it?
Multidrug-resistant tuberculosis (MDR-TB), defined as resistance to at least rifampicin and isoniazid, poses a major threat to public health and TB control worldwide. According to the World Health Organization (WHO), MDR-TB accounted for 480,000 new cases of TB in 2013, of which 9% were extensively drug-resistant TB (XDR-TB), defined as MDR-TB with resistance to a fluoroquinolone and at least o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Mycobacteriology
سال: 2013
ISSN: 2212-5531
DOI: 10.1016/j.ijmyco.2013.09.002